Upsets and ranked vs. ranked matchups across the country in Week 5 of the College Football season have set up a vastly different set of rankings for Week 6. Oregon, Arkansas, Notre Dame, Florida, Ole Miss, and Fresno State all suffered their first loss last week. That meant some major shuffling had to take place, especially up near the top.

No. 9 Michigan enters the top ten of the AP Poll for the first time since Week 2 of 2019 following their win over Wisconsin last Saturday. That was the first win in Madison for the Wolverines since 2001 as Michigan has gotten off to its best start since 2016.

They are one of four Big Ten teams in the AP top ten this week and one of five in the top 15. The highest-ranked teams from the Big Ten, No. 3 Iowa and No. 4 Penn State, face off this week in the biggest matchup between ranked teams.

Check out what the schedule looks like for the entire AP Top 25 in Week 6.

Thursday, October 6

No. 15 Coastal Carolina (5-0) at Arkansas State (1-4)

The No. 15 Coastal Carolina Chanticleers continue to do exactly what they need to do every week. For a Sun Belt Conference team like Coastal Carolina, what they need to do is destroy every opponent in front of them. They have put up 48.2 points per game in their five straight wins to start the 2021 season.

Coastal should have no problem this week as they take on one of the bottom dwellers in the Sun Belt Conference in Arkansas State. The biggest test left on the Chanticleers' schedule is their game next week with Appalachian State.

Friday, October 7

No. 22 Arizona State (4-1) vs. Stanford (3-2)

The Pac-12 teams with the biggest wins in Week 5 will meet on Friday in Week 6. No. 22 Arizona State flexed its muscles against UCLA last week, running away with a 42-23 win on the road. Meanwhile, Stanford pulled off a miraculous comeback to hand No. 8 Oregon their first loss of the season.

The Sun Devils now hold the best chance to win not just the Pac-12 South, but the entire conference. Only Arizona State, Utah, and Oregon State remain undefeated in conference matchups this season.

No. 5 Cincinnati (4-0) vs. Temple (3-2)

Cincy is coming off the heels of perhaps the biggest win in program history after their win at Notre Dame last week. With Oregon's loss, the path for the Bearcats to make the College Football Playoff is clearer than ever.

The downfall of the Cincy team, however, could be the remainder of their schedule. This week's matchup with Temple is the beginning of their year in the American Athletic Conference before they move to the Big 12. That means they will play a bunch of inferior opponents the rest of the way, giving them no real chance to improve their CFP resume. The only ranked opponent left on their schedule is No. 24 SMU.

Saturday, October 8

No. 25 San Diego State (4-0) vs. New Mexico (2-3)

The San Diego State Aztecs are the newest member of the Top 25 this week, replacing Clemson as the last ranked team. SDSU is undefeated, has two wins against Power 5 teams, and is averaging 36.8 points per game through four outings in 2021.

With Boise State's loss to Nevada, the Aztecs are now the front runners for the Mountain West Conference Championship. They are almost 20-point favorites against New Mexico as of Tuesday. They should roll on against the Wolfpack.

No. 24 SMU (5-0) at Navy (1-3)

Despite winning by nearly 30 points in Week 5, the SMU Mustangs fell three spots in the latest AP Top 25 rankings. Room needed to be made for teams like Kentucky, Arizona State, and Texas, but SMU might feel a bit slighted to be the team moved. They are still unbeaten, have a win against a Power 5 team on their resume, and they have only impressed through their first five games.

Navy has struggled out of the gate, losing three-in-a-row to start the year before rebounding last week for their first win. Any matchup with one of the Military Academies is the last matchup a team wants to overlook. This should serve as a great test for how well the SMU coaching staff can get a game plan ready.

No. 20 Florida (3-2) vs. Vanderbilt (2-3)

Florida suffered another setback, falling to Kentucky for the second loss of their season. With two SEC losses already, their conference title hopes are all but squashed. Just another season in Gainesville that is over before the halfway point.

On the flip side, Vanderbilt picked up their second win of the year, proving they are better than UConn at least. Florida will win, and win big.

No. 19 Wake Forest (5-0) at Syracuse (3-2)

Wake Forest is quietly positioning itself as the frontrunner in the ACC. The Demon Deacons escaped an upset scare against Louisville last week to stay undefeated. With a 3-0 record in ACC play, they sit comfortably atop the ACC Atlantic division through five weeks.

Syracuse, on the other hand, is on the complete opposite side of the competitive spectrum. Their ACC-title dreams went up in smoke as they gifted Florida State their first win of the season. The Orange start the hardest stretch of their season, hosting Wake and Clemson in back-to-back weeks before traveling to Blacksburg to take on Virginia Tech.

No. 16 Kentucky (5-0) vs. LSU (3-2)

Things changed quickly for the Wildcats as they hot up the rankings following their upset of Florida. Froom unranked in Week 5 to No. 16 in Week 6, the expectations for this team are going through the roof.

However, the Cats will have to take on LSU without their starting nose tackle. Senior Marquan McCall will be "out for a little bit" according to head coach Mark Stoops. With McCall out, Kentucky will have to turn to underclassmen Justin Rogers and Josiah Hayes. They split time filling in for McCall after he went down during the Florida game.

No. 14 Notre Dame (4-1) at Virginia Tech (3-1)

The Fighting Irish saw their worst nightmares come to fruition last week as No. 5 Cincinnati dominated Notre Dame in their own stadium. Now, head coach Brian Kelly's team is seemingly eliminated from the College Football Playoff hunt before the season has even reached its halfway point.

Notre Dame's schedule would usually allow for them to make up ground after just one loss. However, as it stands currently, the Fighting Irish will not face another ranked team for the rest of the season. A win in Blacksburg this week would be impressive, but it likely will not be eye-popping enough on a CFP-resume for the Fighting Irish to make it a marquee game.

No. 13 Arkansas (4-1) at No. 17 Ole Miss (3-1)

It seems fitting that the teams that suffered the most humiliating losses in Week 5 will face off against each other in Week 6. Neither Arkansas nor Ole Miss was quite capable of competing with their respective matchups with the best their conference has to offer. Now, they will get the chance to prove who leads the pack of the next tier down.

Ole Miss seemingly has the edge, if only because they will be at home. They also have the edge at the most important position; quarterback. Even against that fierce Alabama defense, Matt Corral looked like a poised, well-coached QB. He finished 21/29 with 213 yards and a TD in the 21-point loss to the Crimson Tide.

No. 11 Michigan State (5-0) at Rutgers (3-2)

Michigan State continues to chug along in its second year under head coach Mel Tucker. Noticeable improvements to the offense and special teams have allowed the Spartans to become much more explosive than anyone would have predicted. Entering Week 6, they are putting up 36.8 points per game (No. 17 in the nation) after averaging an abysmal 18 ppg in 2020.

Rutgers should not be slept on, however; Greg Schiano's Scarlet Knights were on the upswing before suffering back-to-back losses against Michigan and Ohio State. This team will be desperately looking for a win to get their season back on track. MSU should be safe, but the Spartans should be aware of the potential of a trap game in this part of their season.

No. 10 BYU (5-0) vs. Boise State (2-3)

This is not a game the BYU Cougars should overlook; in fact, this may be the toughest game left on their schedule. Noise State could easily be 4-1 at this point; a late collapse against UCF and a controversial call in the Oklahoma State game resulted in two critical losses for the Broncos. Had a couple of plays gone their way, Boise State may be ranked heading into this matchup as well.

BYU will need to find a way to shut down QB Hank Bachmeier. The junior-QB has already thrown for over 1500 yards through five games this season. As he goes, the Boise State offense goes. If the Cougars' defense can game plan well enough to shut him down, they should have no problem staying undefeated. Easier said than done, however.

No. 9 Michigan (5-0) at Nebraska (3-3)

Michigan got a major monkey off their back by beating Wisconsin last week in Madison. That was the Wolverines' first win at Wisconsin since 2001, a full 20-year drought. Now, an undefeated Michigan team has soaring expectations after passing their first major test of the season.

Their next test will come on the road against a surging Nebraska team. After an embarrassing loss to Illinois to start the season, Scott Frost's team has rebounded in the past few weeks. They gave real scares to Oklahoma and Michigan State before hanging 56 points on Northwestern in Week 5. Can Michigan win back-to-back road games against major opponents?

No. 7 Ohio State (4-1) vs. Maryland (4-1)

Ohio State went back to doing what they do in Weeks 4 and 5. A week after hanging 59 points on Akron, they produced another 50+ point performance a week later, this time on the road against Big Ten-foe Rutgers.

Meanwhile, Maryland QB Taulia Tagovailoa had his worst performance of the season against Iowa in Week 5. He entered the game with 10 TD passes to just 1 interception; after Iowa left town, he had 12 TDs to 6 INTs. Whether or not Tua's younger brother can bounce back from a performance like that is yet to be seen.

No. 6 Oklahoma (5-0) vs. No. 21 Texas (5-1)

Neutral Site Game- Cotton Bowl, Dallas, Texas

The last Red River Rivalry game under the banner of the Big 12 is one of the biggest games of the week. Oklahoma is still undefeated, but the Sooners have not looked like they have in recent years under Lincoln Riley. Outside of their blowout win over Western Carolina, all of Oklahoma's wins have come by only one score. The Oklahoma offense is not pulling away from other teams like they are accustomed to.

Does that mean Texas has a shot to upset their rivals? Possibly. The Longhorns' offense has seemingly found its way after making the change to Casey Thompson at QB. Since their loss to Arkansas, Texas is averaging 53 PPG in three straight wins. They have the offense to score with Oklahoma; the question is whether their defense can slow the Sooners down enough times to come out on top.

No. 3 Iowa (5-0) vs. No. 4 Penn State (5-0)

Undoubtedly, the biggest game of Week 6 takes place in Iowa City. Both Penn State and Iowa enter the game undefeated, leading the pack in their respective divisions in the Big Ten and boasting sky-high expectations. The winner of this game will be the No. 1 contender to represent the Big Ten in the College Football Playoff.

Throw out the stats. Throw out the schemes, the tape. None of it matters. Winning on the road at night at Kinnick is almost impossible. Even with a 4 PM EST start, it is unlikely this Penn State team is going to be the one to crack the code. Iowa stays undefeated.

No. 2 Georgia (5-0) at No. 18 Auburn (4-1)

After these past couple of weeks, it seems the QB controversy in Athens was unimportant. Because against Arkansas and Vanderbilt, it seemingly did not matter who played the position; Georgia was going to roll their opponents either way.

This is the turning point of the season for the Auburn Tigers. Their loss to Penn State did not take away from their goals necessarily, but a loss to Georgia would. On the other hand, an upset win over Georgia would put them in the driver's seat for the SEC West. Is that unlikely? Sure. But we have seen unlikely moments in Georgia vs. Auburn matchups before.

No. 1 Alabama (5-0) at Texas A&M (3-2)

A few weeks ago, this matchup was building to be one of the premier SEC matchups of the midway point in the season. Now, it is tough to see a way Texas A&M bests the Crimson Tide. Backup QB Zach Calzada has been up-and-down since being forced into the starting role. Now, he will be tasked with engineering an upset of College Football's greatest dynasty.

This game will feature the two best running backs in the SEC. A&M's Isaiah Spiller is coming off a 100-yard rushing performance in the Aggies' loss to Mississippi State last week. Meanwhile, Bama's Brian Robinson Jr. went for 171 yards and 4 TDs in Alabama's win over Ole Miss.